Lithium hydroxide, monohydrate → HCID 57979889, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (0.078 g, 1.86 mmol) was added to a stirred solution of methyl N-[(benzyloxy)carbonyl]-O-isopropyl-L-serinate (0.432 g, 1.47 mmol) in a mixture of tetrahydrofuran/water (10 ml, 1:1) at 0° C. The reaction mixture was stirred overnight, acidified with a 10% w/v aqueous solution of potassium hydrogensulfate and extracted with EtOAc (2×30 ml). The organic layers were combined, dried over magnesium sulfate, filtered and concentrated to give N-[(benzyloxy)carbonyl]-O-isopropyl-L-serine as a clear colourless oil, (0.346 g, 84%); 1H NMR Spectrum: (CDCl3) 1.14 (m, 6H), 3.64 (m, 2H), 3.95 (m, 1H), 4.49 (m, 1H), 5.14 (s, 2H), 5.62 (d, 1H), 7.36 (m, 5H).

Provenance & Evidence