Sodium Hydroxide → HCID 67371312, compound

HRID 1867795Notes

Reaction equation

HRID 1867795 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16](=[O:18])[CH3:17])=[CH:12][N:11]=2)=[CH:6][CH:5]=1.[OH-].[Na+:21]>O1CCCC1.C(O)C>[Na+:21].[C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([O-:19])=[O:2])=[CH:5][CH:6]=2)=[N:11][CH:12]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57980135HCID 57980135, compound

Product 1

HCID 67371312HCID 67371312, compound

Reagents, catalysts & solvents 1

HCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

Procedure V′: To a stirring solution of 4-(5-acetyl-pyridin-2-yl)-benzoic acid methyl ester (1.0 mmol) in 1:1 tetrahydrofuran/ethanol (0.20M), add 2N sodium hydroxide and heat to reflux for three hours. After this time, concentrate the reaction in vacuo. Rinse the solid with dichloromethane and decant. The title compound, remaining as a solid, requires no further purification. MS (m/e): 242.1 (M+1)

Workup

  1. temperatureheat
  2. temperatureto reflux for three hours
  3. concentrationAfter this time, concentrate
  4. customthe reaction in vacuo
  5. washRinse the solid with dichloromethane
  6. customdecant
  7. customno further purification

Sources & evidence

ORD record
ord-3c8fe183982042e384d03441599b0dbb
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

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