Sodium Hydroxide → HCID 57980122, compound

HRID 1867822Notes

Reaction equation

HRID 1867822 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([N:17]([S:19]([CH3:22])(=[O:21])=[O:20])[CH3:18])=[CH:13][CH:12]=2)=[CH:7][C:6]=1[F:23])=[O:4].[OH-].[Na+]>CO.O1CCCC1>[F:23][C:6]1[CH:7]=[C:8]([C:11]2[CH:12]=[CH:13][C:14]([N:17]([S:19]([CH3:22])(=[O:21])=[O:20])[CH3:18])=[CH:15][CH:16]=2)[CH:9]=[CH:10][C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57980131HCID 57980131, compound

Product 1

HCID 57980122HCID 57980122, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Procedure UU: To a stirring solution of 3-Fluoro-4′-(methanesulfonyl-methyl-amino)-biphenyl-4-carboxylic acid methyl ester (see Intermediate Preparation 33) (11.0 mmol) in 1:1 methanol/tetrahydrofuran, add 2N sodium hydroxide (3.0 mmol) and stir at room temperature for 4 hours. After this time wash the reaction with 1N hydrochloric acid while extracting with dichloromethane. Dry the organics with sodium sulfate, decant, and concentrate in vacuo. MS (m/e): 322.1 (M−1)

Workup

  1. washAfter this time wash
  2. customthe reaction with 1N hydrochloric acid
  3. extractionwhile extracting with dichloromethane
  4. dry with materialDry the organics with sodium sulfate
  5. customdecant
  6. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-e3bdc92f447a42d6b22eb378fecacc7d
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

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