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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867824Generated: November 3, 2026

3-(Trifluoromethyl)phenylboronic acid → (3-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

https://huagongshe.com/reaction/1867824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
Reactant(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 11965125—
Product(3-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 57980051—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 3-Trifluoromethyl benzene boronic acid. MS (M+H) 421.1

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632857B2
Source datasetuspto-grants-2009_12
ORD IDord-d7dcd6c84f424be3a4a37c5ee0d6db9e
Source noteuspto-grants-2009_12