4-(Trifluoromethoxy)phenylboronic acid → (3-Fluoro-4'-trifluoromethoxy-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	4-(Trifluoromethoxy)phenylboronic acid	HCID 2734386	—
Reactant	(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone	HCID 11965125	—
Product	(3-Fluoro-4'-trifluoromethoxy-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone	HCID 57980149	—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-Trifluoromethoxybenzene boronic acid. MS (M+H) 437.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07632857B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-205ab6758e7e46a099b1e40bb02f95db
Source note	uspto-grants-2009_12