4-(Ethylsulphonyl)benzeneboronic acid → HCID 57980096, compound

HRID 1867835Notes

Reaction equation

HRID 1867835 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([F:21])[CH:3]=1.[CH2:22]([S:24]([C:27]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29][CH:28]=1)(=[O:26])=[O:25])[CH3:23]>>[CH2:22]([S:24]([C:27]1[CH:32]=[CH:31][C:30]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:14][CH2:13][CH2:12][C@H:11]3[CH2:15][N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:9])=[C:4]([F:21])[CH:3]=2)=[CH:29][CH:28]=1)(=[O:25])=[O:26])[CH3:23]

Participants

3

Reactant 2

HCID 27734204-(Ethylsulphonyl)benzeneboronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 57980096HCID 57980096, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-Ethylsulfonyl benzene boronic acid. MS (M+H) 445.2

Sources & evidence

ORD record
ord-2ada93686c594588a1b2f16492cb6384
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

Loading…