HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethylpyrrolidine, (2S,5S)- → [2-(2,5-cis-Dimethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethylpyrrolidine, (2S,5S)- | HCID 6994099 | — |
| Reactant | (2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone | HCID 57980177 | — |
| Product | [2-(2,5-cis-Dimethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone | HCID 67372989 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure RR starting from (2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4′-trifluoromethyl-biphenyl-4-yl)-methanone and mixture of cis and trans-2,5-dimethyl-pyrrolidine. MS (M+H) 431.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632857B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-f38b7dc0610f4faaa9b4909fb5aa0780 |
| Source note | uspto-grants-2009_12 |