(2S)-2-(Fluoromethyl)pyrrolidine → [2-(S)-(2-(S)-Fluoromethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2-(Fluoromethyl)pyrrolidine	HCID 51980281	—
Reactant	(2-(S)-Hydroxymethyl-pyrrolidin-1-yl)-(4'-trifluoromethyl-biphenyl-4-yl)-methanone	HCID 57980177	—
Product	[2-(S)-(2-(S)-Fluoromethyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-(4'-trifluoromethyl-biphenyl-4-yl)-methanone	HCID 57980052	—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure RR starting from (2-(S)-hydroxymethyl-pyrrolidin-1-yl)-(4′-trifluoromethyl-biphenyl-4-yl)-methanone and 2-(S)-Fluoromethyl-pyrrolidine (CAS 460748-85-0) MS (M+H) 435.2

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07632857B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-5dd169f224cb4685878b442881eef3c3
Source note	uspto-grants-2009_12