反应详情

Procedure VV: To a stirring solution of 2-Ethanesulfonyl-5-iodo-pyridine (1.0 mmol) and (4-carboxy-3-fluorophenyl)boronic acid (1.3 mmol) in dioxane (0.1M), add dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane complex (0.03 mmol) and 2M aqueous sodium carbonate (3.0 mmol). Heat the reaction to reflux for 4 hours. After this time, remove the heat and concentrate in vacuo. Wash with dichloromethane while extracting with water. Acidify the aqueous layer with 1N hydrochloric acid and extract with 10% isopropanol/dichloromethane four times. Combine the organics, dry with sodium sulfate, decant and concentrate in vacuo. MS (m/e): 310.3 (M+1)

1. temperatureHeat
2. customthe reaction
3. temperatureto reflux for 4 hours
4. customAfter this time, remove the
5. temperatureheat
6. concentrationconcentrate in vacuo
7. washWash with dichloromethane
8. extractionwhile extracting with water
9. extractionextract with 10% isopropanol/dichloromethane four times
10. dry with materialCombine the organics, dry with sodium sulfate
11. customdecant
12. concentrationconcentrate in vacuo