(Pyrimidin-5-yl)boronic acid → HCID 57980141, compound

HRID 1867858Notes

Reaction equation

HRID 1867858 reaction equation
[N:1]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3][CH:2]=1.Br[C:11]1[CH:16]=[C:15]([F:17])[C:14]([C:18]([N:20]2[CH2:24][CH2:23][CH2:22][C@H:21]2[CH2:25][N:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[O:19])=[C:13]([F:31])[CH:12]=1>>[F:17][C:15]1[CH:16]=[C:11]([C:5]2[CH:6]=[N:1][CH:2]=[N:3][CH:4]=2)[CH:12]=[C:13]([F:31])[C:14]=1[C:18]([N:20]1[CH2:24][CH2:23][CH2:22][C@H:21]1[CH2:25][N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:19]

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 11965202HCID 11965202, compound

Product 1

HCID 57980141HCID 57980141, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure WW starting from 5-pyrimidine boronic acid and (4-bromo-2,6-difluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone to give 8 mg (8%). MS (ES+) 373 m/z

Workup

  1. customto give 8 mg (8%)

Sources & evidence

ORD record
ord-0f79ddfc6ed6472a80632732b369ae63
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

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