(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)acetohydrazide
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[N:24]=[N:23][C:22]([NH:25][NH:26]C(=O)CC2CCOCC2)=[CH:21][C:20]=1[C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH:26][NH:25][C:22]2[N:23]=[N:24][C:19]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[Cl:12])=[C:20]([C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=3)[CH:21]=2)=[O:11])=[CH:6][CH:7]=1참가 물질
3
실험 절차
The title compound (90 mg, 62%) as a white solid was prepared from 2-(4-chlorophenyl)acetic acid (62 mg, 0.36 mmol) and 1-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3)hydrazine (99 mg, 0.3 mmol) according to the procedures described for N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-(tetrahydro-2H-pyran-4-yl)acetohydrazide (Example 9A). HPLC/MS (method A): retention time=3.57 min, (M+H)+=483.2.
출처 및 근거
- ORD 기록
- ord-f5cbcde857ac402bad5d1312ca1af7e3
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07632837B2
반응 노트
불러오는 중…