HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine → 3-(4-Chlorobenzyl)-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993108 | — |
| Reactant | Triphenylphosphane dichloride | HCID 13797396 | — |
| Reactant | 2-(4-chlorophenyl)-N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)acetohydrazide | HCID 57979753 | — |
| Product | 3-(4-Chlorobenzyl)-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993111 | 54% |
Reaction Steps
The title compound (50 mg, 54%) as a white powder was prepared from 2-(4-chlorophenyl)-N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)acetohydrazide (96 mg, 0.2 mmol) and triphenylphosphine dichloride (220 mg,0.66 mmol) according to the procedures described for 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine (Example 7B). HPLC/MS (method A): retention time=4.12 min, (M+H)+=465.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632837B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-d397fa5ec9954711bf8041bf622dbb4d |
| Source note | uspto-grants-2009_12 |