HRID1867891

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID51695709

未命名化合物

结构：NNc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)cn1

HCID57799387

5-(2-Chlorophenyl)-4-(4-chlorophenyl)-2-hydrazinylpyridine

C17H13Cl2N3

结构：O=C(Cc1ccc(C(F)(F)F)cc1)NNc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)nn1

HCID57979748

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1ccc(C(F)(F)F)nc1)NNc1cc(-c2ccc(Cl)cc2)c(-c2ccccc2Cl)cn1

HCID57979743

未命名化合物

收率 103.1%

PROCEDURE

实验过程

The title compound (40 mg, 100%) as a white solid was prepared from 5-(2-chlorophenyl)-4-(4-chlorophenyl)-2-hydrazinylpyridine (25 mg, 0.075 mmol) and 2-(6-(trifluoromethyl)pyridin-3-yl)acetic acid (23 mg, 0.113 mmol) in a manner analogous to that in which N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-(4-(trifluoromethyl)phenyl)acetohydrazide (Example 11A) was prepared. HPLC/MS: retention time=3.53 min, [M+H]+=517.1.

WORKUP

后处理

customwas prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca5ca5a843654322a824ac162428ddf8
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07632837B2
来源说明: uspto-grants-2009_12

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[CH:10][C:11]([NH:14][NH2:15])=[N:12][CH:13]=1.[F:23][C:24]([F:36])([F:35])[C:25]1[N:30]=[CH:29][C:28]([CH2:31][C:32](O)=[O:33])=[CH:27][CH:26]=1.ClC1C=CC=CC=1C1N=NC(NNC(=O)CC2C=CC(C(F)(F)F)=CC=2)=CC=1C1C=CC(Cl)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[CH:10][C:11]([NH:14][NH:15][C:32](=[O:33])[CH2:31][C:28]2[CH:29]=[N:30][C:25]([C:24]([F:23])([F:36])[F:35])=[CH:26][CH:27]=2)=[N:12][CH:13]=1