2,2,2-Trifluoroethanol → 6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo[4,3-a]pyridine

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Reaction Steps

The title compound (21 mg, 48% yield) as a white powder was prepared from 3-chloro-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridine (38 mg, 0.1 mmol), 2,2,2-trifluoroethanol (72 μL, 1.0 mmol), 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine (144 μL, 0.5 mmol) and anhydrous THF (0.5 mL)in a manner analogous to that in which 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo[4,3-a]pyridazine (Example 6) was prepared. HPLC/MS: retention time=3.86 min, [M+H]+=438.1.

Provenance & Evidence