HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2,4-Dimethoxybenzyl)-7-(2-(s)-hydroxymethyl-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 1-(2,4-dimethoxybenzyl)-7-(2-(s)-hydroxymethyl-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylate | HCID 69029517 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2,4-Dimethoxybenzyl)-7-(2-(s)-hydroxymethyl-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid | HCID 69029566 | — |
Reaction Steps
A mixture of EXAMPLE 1C (2 g) and 0.1M lithium hydroxide (80 mL) in ethanol (100 mL) at 25° C. was stirred for 24 hours, adjusted to pH 3 with 1M hydrochloric acid, treated with water, and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632946B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-850c3751de184642b54d996d0074eb5f |
| Source note | uspto-grants-2009_12 |