HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2,4-Dimethoxybenzyl)-7-(2-(r)-hydroxymethyl-piperidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 1-(2,4-dimethoxybenzyl)-7-(2-hydroxymethylpiperidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylate | HCID 69030307 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2,4-Dimethoxybenzyl)-7-(2-(r)-hydroxymethyl-piperidin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid | HCID 69032246 | — |
Reaction Steps
A mixture of EXAMPLE 5A (2.3 g) and 0.1M lithium hydroxide (90 mL) in ethanol (110 mL) was stirred for 16 hours, adjusted to pH 3 with 1M hydrochloric acid, treated with water, and extracted with dichloromethane. The extract was concentrated, and the concentrate was recrystallized from ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632946B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-7dbd37be71d548dcbf68616a17e5e6f4 |
| Source note | uspto-grants-2009_12 |