Hydrochloric Acid → HCID 68976129, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6c (132 mg, 0.35 mmol) in EtOH (5 mL) 0.469 g of a freshly prepared solution of potassium hydroxide (253.2 mg in 5.013 g H2O, 0.045M, 1.1eq.) was added. The mixture was stirred at 23-25° C. for 1 h (completion monitored by TLC) and neutralized with 0.1% HCl (neutral by pH indicator paper). Solvent was evaporated in vacuo and the residue dissolved in ethyl acetate and flash filtered through a pad of silica gel to remove inorganic impurities. The silica gel was washed with ethyl acetate, fractions combined and solvent evaporated in vacuo to afford 107 mg (92%) of 6e.

Provenance & Evidence