HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → 4-(2-Hydroxy-2-methylpropylamino)benzene-sulfonic acid 2-[(piperidine-4-carbonyl)amino]benzothiazol-6-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 4-(4-(Pyridin-3-yl)-1H-imidazol-1-yl)butan-1-amine | HCID 11042160 | — |
| Reactant | 4-Fluorobenzenesulfonic 2-[(piperidine-4-carbonyl)amino]-benzothiazol-6-yl ester | HCID 57980845 | — |
| Product | 4-(2-Hydroxy-2-methylpropylamino)benzene-sulfonic acid 2-[(piperidine-4-carbonyl)amino]benzothiazol-6-yl ester | HCID 11497060 | — |
Reaction Steps
A solution of 4-fluorobenzenesulfonic 2-[(piperidine-4-carbonyl)amino]benzo-thiazol-6-yl ester (intermediate 4) (50 mg, 0.114 mmol) and of 4-(4-pyrid-3-yl-imidazol-1-yl)butylamine (40.93 mg, 0.459 mmol) in 0.5 ml of NMP is heated at 130° C. by microwave for 5 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 21 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester (pale yellow solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632952B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-e0e208052fce482aad1c5dffba83f802 |
| Source note | uspto-grants-2009_12 |