HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentylamine → 4-Cyclopentylaminobenzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | 4-Fluorobenzenesulfonic acid 2-(cyclopropanecarbonylamino)-benzothiazol-6-yl ester | HCID 11523999 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-Cyclopentylaminobenzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester | HCID 11604957 | — |
Reaction Steps
A solution of 4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester (example 7) (50 mg, 127.4 μmol) and cyclopentylamine (51 μl, 0.51 mmol) in 0.5 ml of NMP is heated at 150° C. by microwave for 5 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 38 mg of 4-cyclopentylamino-benzenesulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester (white solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632952B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-f967e4eb8bcd43c8a7e6cf2c522e8f3d |
| Source note | uspto-grants-2009_12 |