HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Ethanediamine, N1,N1-bis(1-methylethyl)- → 4-(2-Diisopropylaminoethylamino)benzenesulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Ethanediamine, N1,N1-bis(1-methylethyl)- | HCID 8459 | — |
| Reactant | 4-Fluorobenzenesulfonic acid 2-(cyclopropanecarbonylamino)-benzothiazol-6-yl ester | HCID 11523999 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(2-Diisopropylaminoethylamino)benzenesulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester | HCID 11684975 | — |
Reaction Steps
A solution of 4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester (example 7) (100 mg, 255 μmol) and N,N-diisopropyl-ethane-1,2-diamine (147 mg, 1.02 mmol) in 2 ml of NMP is heated at 110° C. by microwave for 10 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 66 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclopropanecarbonyl-amino)benzothiazol-6-yl ester (beige-colored solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632952B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-7812bb8b14454e31bb4e2ede62cb3923 |
| Source note | uspto-grants-2009_12 |