4-(4-(Pyridin-3-yl)-1H-imidazol-1-yl)butan-1-amine → 4-[4-(4-Pyrid-3-ylimidazol-1-yl)butylamino]-benzenesulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester

Participants

Reaction Steps

A solution of 4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester (example 7) (50 mg, 127.4 μmol) and 4-(4-pyrid-3-ylimidazol-1-yl)butylamine (110.2 mg, 0.51 mmol) in 0.5 ml of NMP is heated at 150° C. by microwave for 8 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 36 mg of 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic 2-(cyclo-propanecarbonylamino)benzothiazol-6-yl ester (beige-colored solid).

Provenance & Evidence