Water → 4-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester

Participants

Reaction Steps

A solution of 4-fluorobenzenesulfonic acid 2-tert-butoxycarbonylaminobenzo-thiazol-6-yl ester (intermediate 15) (1.7 g, 3.60 mmol), 10 ml of trifluoroacetic acid (130 mmol) in 10 ml of dichloromethane, and 1 ml of water, in a 100 ml round-bottomed flask equipped with a magnetic bar, is stirred for 2 hours at room temperature. The reaction medium is evaporated to dryness and the residue obtained is washed with ethyl ether to give 1.31 g of 4-fluoro-benzenesulfonic acid 2-aminobenzothiazol-6-yl ester in the form of the trifluoroacetic acid salt (white powder) in a yield of 83%.

Provenance & Evidence