HCID 54758947, compound → HCID 86761027, compound

HRID 1867968Notes

Reaction equation

HRID 1867968 reaction equation
C(O[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:18][C:19]1[S:20][C:21]2[CH:27]=[C:26]([O:28][S:29]([C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)(=[O:31])=[O:30])[CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:17])=[O:7])(C)(C)C.NC1SC2C=C(OS(C3C=CC(F)=CC=3)(=O)=O)C=CC=2N=1.C(C(CCCCCCN)C(O)=O)([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=O>>[C:63]([O:62][CH:9]([N:8]=[C:6]=[O:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:18][C:19]1[S:20][C:21]2[CH:27]=[C:26]([O:28][S:29]([C:32]3[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=3)(=[O:30])=[O:31])[CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:17])([CH3:66])([CH3:65])[CH3:64]

Participants

4

Reactant 3

HCID 54758947HCID 54758947, compoundHCID 579808144-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester2×HCID 57980842HCID 57980842, compound

Product 1

HCID 86761027HCID 86761027, compound

Procedure

According to the method of intermediate 17, 4-fluorobenzenesulfonic acid 2-(8-tert-butoxycarbonylaminooctanoylamino)benzothiazol-6-yl ester is pre-pared by combining 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16) with Boc-8-aminocaprylic acid.

Sources & evidence

ORD record
ord-4a924c4dadb444c78fa22b56bee5c5ec
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

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