Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 18470676 | HCID 18470676 | — |
| Reactant | 4-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester | HCID 57980814 | — |
| Product | HCID 86761028 | HCID 86761028 | — |
Reaction Steps
A solution of 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16, brevetbenzothiazole_V2) (0.15 g, 0.46 mmol), BOC-6-aminohexanoic acid (0.128 g, 0.555 mmol), HATU (0.211 g, 0.555 mmol) and N,N-diisopropylethylamine (95 μl, 0.555 mmol) in 2 ml of DMF, in a 20 ml round-bottomed flask equipped with a magnetic bar, is heated at about 60° C. (ext.) for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07632952B2 |
|---|
| Source dataset | uspto-grants-2009_12 |
|---|
| ORD ID | ord-ff366f308e334ccaade691991e6d98cd |
|---|
| Source note | uspto-grants-2009_12 |
|---|
