HCID 53442822, compound → HCID 86761029, compound

HRID 1867982Notes

Reaction equation

HRID 1867982 reaction equation
C(O[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([O:27][S:28]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)(=[O:30])=[O:29])[CH:24]=[CH:23][C:21]=2[N:22]=1)=[O:16])=[O:7])(C)(C)C.NC1SC2C=C(OS(C3C=CC(F)=CC=3)(=O)=O)C=CC=2N=1.C(C(CCCCCN)C(O)=O)([O:61][C:62]([CH3:65])([CH3:64])[CH3:63])=O>>[C:62]([O:61][CH:9]([N:8]=[C:6]=[O:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[S:19][C:20]2[CH:26]=[C:25]([O:27][S:28]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)(=[O:29])=[O:30])[CH:24]=[CH:23][C:21]=2[N:22]=1)=[O:16])([CH3:65])([CH3:64])[CH3:63]

Participants

4

Reactant 3

HCID 53442822HCID 53442822, compoundHCID 57980809HCID 57980809, compoundHCID 579808144-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester2×

Product 1

HCID 86761029HCID 86761029, compound

Procedure

According to the method of intermediate 46, 4-fluorobenzenesulfonic acid 2-(7-tert-butoxycarbonylaminoheptanoylamino)benzothiazol-6-yl ester is prepared via the action of 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16, brevetbenzothiazole_V2) with BOC-7-amino-heptanoic acid to give 0.164 g of product.

Sources & evidence

ORD record
ord-370ead3e1e7f40cbb47ba15e7418e00a
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

Loading…