Isobutyric Acid → HCID 86761030, compound

HRID 1867984Notes

Reaction equation

HRID 1867984 reaction equation
C(N[C:7]1[S:8][C:9]2[CH:15]=[C:14]([O:16][S:17]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH:13]=[CH:12][C:10]=2[N:11]=1)(=O)C(C)C.[NH2:27]C1SC2C=C(OS(C3C=CC(F)=CC=3)(=O)=O)C=CC=2N=1.[C:48]([OH:53])(=O)[CH:49]([CH3:51])[CH3:50]>>[C:48]([C:7]1[S:8][C:9]2[CH:15]=[C:14]([O:16][S:17]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH:13]=[C:12]([NH2:27])[C:10]=2[N:11]=1)(=[O:53])[CH:49]([CH3:51])[CH3:50]

Participants

4

Reactant 3

HCID 6590Isobutyric AcidHCID 57980802HCID 57980802, compoundHCID 579808144-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester2×

Product 1

HCID 86761030HCID 86761030, compoundYield 86%

Procedure

According to the method of intermediate 46, 4-fluorobenzenesulfonic acid 2-isobutyrylaminobenzothiazol-6-yl ester is prepared via the action of 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16, brevetbenzothiazole_V2) with isobutyric acid. The crude reaction product is crystallized from ethyl ether and, after filtering off by suction, 0.17 g of colorless solid is isolated, i.e. an 86% yield.

Workup

  1. customThe crude reaction product
  2. customis crystallized from ethyl ether
  3. filtrationafter filtering off by suction

Sources & evidence

ORD record
ord-170f16d590c94009a4195eaf604c6983
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

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