1-(3,5-Dichloropyridin-4-yl)piperazine → 2-Chlorobenzenesulfonyl chloride

HRID 1868006Notes

Reaction equation

HRID 1868006 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](N1CCN(C2C(Cl)=CN=CC=2Cl)CC1)(=[O:10])=[O:9].[Cl:25]C1C=NC=C(Cl)C=1N1CCNCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([Cl:25])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazineHCID 3775440HCID 3775440, compound

Product 1

HCID 761872-Chlorobenzenesulfonyl chlorideYield 59%

Procedure

In an analogous manner to Example 1F, step 1Q 1-[(2-chlorophenyl)sulfonyl]-4-(3,5-dichloropyridin-4-yl)piperazine was prepared from 1-(3,5-dichloro-4-pyridyl)piperazine (0.1 g, 0.43 mmol) and 2-chlorobenzene sulfonyl chloride (59% yield).

Sources & evidence

ORD record
ord-fdf6a5b3510d4b98bbf8d6b29e8183e6
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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