1-(3,5-Dichloropyridin-4-yl)piperazine → 3-Chlorobenzenesulphonyl chloride

HRID 1868007Notes

Reaction equation

HRID 1868007 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8](N2CCN(C3C(Cl)=CN=CC=3Cl)CC2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[Cl:25]C1C=NC=C(Cl)C=1N1CCNCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([Cl:25])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazineHCID 68552938HCID 68552938, compound

Product 1

HCID 179093-Chlorobenzenesulphonyl chlorideYield 66%

Procedure

In an analogous manner to Example 1F, step 1Q 1-[(3-chlorophenyl)sulfonyl]-4-(3,5-dichloropyridin-4-yl)piperazine was prepared from 1-(3,5-dichloro-4-pyridyl)piperazine (0.1 g, 0.43 mmol) and 3-chlorobenzene sulfonyl chloride (66% yield).

Sources & evidence

ORD record
ord-9f65f0c390334ba48a9d07aa02277da5
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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