1-(3,5-Dichloropyridin-4-yl)piperazine → (3,4-Dichlorophenyl)methanesulfonyl chloride

HRID 1868008Notes

Reaction equation

HRID 1868008 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][S:6](N1CCN(C2C(Cl)=CN=CC=2Cl)CC1)(=[O:8])=[O:7].[Cl:27]C1C=NC=C(Cl)C=1N1CCNCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][S:6]([Cl:27])(=[O:8])=[O:7])[CH:23]=[CH:24][C:25]=1[Cl:26]

Participants

3

Reactant 2

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazineHCID 24746265HCID 24746265, compound

Product 1

HCID 2794622(3,4-Dichlorophenyl)methanesulfonyl chlorideYield 61%

Procedure

In an analogous manner to Example 1F, step 1Q 1-[(3,4-dichlorobenzyl)sulfonyl]-4-(3,5-dichloropyridin-4-yl)piperazine was prepared from 1-(3,5-dichloro-4-pyridyl)piperazine (0.1 g, 0.43 mmol) and 3,4-dichlorophenylmethyl sulfonyl chloride (61% yield).

Sources & evidence

ORD record
ord-5fb5e28f7ab14f2595da9cc9079fc8e4
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…