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1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Dichloroethane | HCID 6365 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate | HCID 11630777 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | — |
反応手順
To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07632838B2 |
| 出典データセット | uspto-grants-2009_12 |
| ORD ID | ord-30b29d4f567642f38fcd9d67ddf87c72 |
| 出典メモ | uspto-grants-2009_12 |