HCID 57979763, compound → HCID 57979764, compound

HRID 1868027Notes

Reaction equation

HRID 1868027 reaction equation
CS(O[C@H:6]([CH3:23])[CH2:7][N:8]([CH2:19][C@@H:20]([NH2:22])[CH3:21])[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])(=O)=O>CO>[CH3:23][C@H:6]1[NH:22][C@H:20]([CH3:21])[CH2:19][N:8]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:7]1

Participants

3

Reactant 1

HCID 57979763HCID 57979763, compound

Product 1

HCID 57979764HCID 57979764, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

(R)-1-(((S)-2-aminopropyl)(benzyloxycarbonyl)amino)propan-2-yl methanesulfonate (1.8 g, 5.15 mmol) dissolved in anhydrous MeOH (120 mL) was heated up to 60° C. for 4 hours. Reaction was complete as determined by TLC. After overnight stirring at room temperature solvent was evaporated to afford (3R,5R)-benzyl 3,5-dimethylpiperazine-1-carboxylate [L31285-103-1] in quantitative yield (1.28 g) as gummy off white solid.

Workup

  1. customReaction
  2. customwas evaporated

Sources & evidence

ORD record
ord-76a47e6dbc6e4443a129abd098429900
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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