HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-(trifluoromethyl)pyridine → 2-[4-(2-Naphthylsulfonyl)piperidin-1-yl]-5-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| Reactant | 4-(2-Naphthylsulfonyl)piperidine | HCID 22721937 | — |
| Product | 2-[4-(2-Naphthylsulfonyl)piperidin-1-yl]-5-(trifluoromethyl)pyridine | HCID 68552143 | 84% |
Reaction Steps
Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (130 mg, 0.51 mmol) was reacted with 2-chloro-5-(trifluoromethyl)pyridine (181 mg, 1.0 mmol) to afford the title compound (180 mg), a white solid, in 84% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-f8fc53c95b14459585fab76e84be2e03 |
| Source note | uspto-grants-2009_12 |