2-Chloro-5-nitropyridine → HCID 68554253, compound

HRID 1868044Notes

Reaction equation

HRID 1868044 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12].Cl[C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][N:22]=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][N:17]([C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][N:22]=2)[CH2:16][CH2:15]1)(=[O:12])=[O:13]

Participants

3

Reactant 2

HCID 783082-Chloro-5-nitropyridineHCID 227219374-(2-Naphthylsulfonyl)piperidine

Product 1

HCID 68554253HCID 68554253, compoundYield 31.1%

Procedure

Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (Example 11, Step 3, 130 mg, 0.51 mmol) was reacted with 2-chloro-5-nitropyridine (158 mg, 1.0 mmol) to afford the title compound (63 mg), a yellow solid, in 31% yield.

Sources & evidence

ORD record
ord-4cbcf1d4865640dba9ad49b56f585660
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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