HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinonitrile → 2-[4-(2-Naphthylsulfonyl)piperidin-1-yl]nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Reactant | 4-(2-Naphthylsulfonyl)piperidine | HCID 22721937 | — |
| Product | 2-[4-(2-Naphthylsulfonyl)piperidin-1-yl]nicotinonitrile | HCID 68555393 | 78.4% |
Reaction Steps
Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (Example 11, Step 3, 130 mg, 0.51 mmol) was reacted with 2-chloro-3-cyanopyridine (139 mg, 1.0 mmol) to afford the title compound (151 mg), a white solid, in 78% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-92dad58a56904840a2c0d9e12148a2e4 |
| Source note | uspto-grants-2009_12 |