3,4,5-Trichloropyridine → HCID 68554108, compound

HRID 1868048Notes

Reaction equation

HRID 1868048 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([S:7]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)(=[O:9])=[O:8])[CH2:3][CH2:2]1.[Cl:20][C:21]1[CH:22]=[N:23][CH:24]=[C:25]([Cl:28])[C:26]=1Cl>>[Cl:20][C:21]1[CH:22]=[N:23][CH:24]=[C:25]([Cl:28])[C:26]=1[N:1]1[CH2:6][CH2:5][CH:4]([S:7]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)(=[O:9])=[O:8])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 37865313,4,5-TrichloropyridineHCID 68552056HCID 68552056, compound

Product 1

HCID 68554108HCID 68554108, compoundYield 16%

Procedure

Using the procedure from Example 7A, Step 7E, 2-(piperidin-4-ylsulfonyl)quinoline (150 mg, 0.51 mmol) was reacted with 3,4,5-trichloropyridine (182 mg, 1.0 mmol) to afford the title compound (34 mg), an off-white solid, in 16% yield.

Sources & evidence

ORD record
ord-22a48f0f40e34f35b227445f7b8d7964
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…