2-Chloronicotinonitrile → HCID 68553057, compound

HRID 1868049Notes

Reaction equation

HRID 1868049 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([S:7]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)(=[O:9])=[O:8])[CH2:3][CH2:2]1.Cl[C:21]1[C:26]([C:27]#[N:28])=[CH:25][CH:24]=[CH:23][N:22]=1>>[N:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:18]=[CH:19][C:10]=1[S:7]([CH:4]1[CH2:5][CH2:6][N:1]([C:21]2[N:22]=[CH:23][CH:24]=[CH:25][C:26]=2[C:27]#[N:28])[CH2:2][CH2:3]1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 68552056HCID 68552056, compound

Product 1

HCID 68553057HCID 68553057, compoundYield 86%

Procedure

Using the procedure from Example 7A, Step 7E, 2-(piperidin-4-ylsulfonyl)quinoline (Example 1T, Step 3, 150 mg, 0.51 mmol) was reacted with 2-chloro-3-cyanopyridine (139 mg, 1.0 mmol) to afford the title compound (166 mg), an off-white solid, in 86% yield.

Sources & evidence

ORD record
ord-c4d4a972b0184b07af6015db2e7c0ac6
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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