HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinonitrile → HCID 68548089, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[(3-Chlorophenyl)sulfonyl]piperidine | HCID 53417698 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68548089 | HCID 68548089 | 66.2% |
Reaction Steps
Using the procedure from Example 7A, 4-[(3-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-3-cyanopyridine (108 mg, 0.76 mmol), DIEA (0.2 ml, 1.14) and 1,4-dioxane (0.3 ml) to afford the title compound (91 mg), a yellow solid, in 62% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-08359d21d0f046faa58f4aae4ad9a46a |
| Source note | uspto-grants-2009_12 |