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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1868058Generated: November 3, 2026

2-Chloronicotinonitrile → HCID 68548089, compound

https://huagongshe.com/reaction/1868058

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChloronicotinonitrileHCID 81079—
ReactantDiisopropylethylamineHCID 81531—
Reactant4-[(3-Chlorophenyl)sulfonyl]piperidineHCID 53417698—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68548089HCID 6854808966.2%

Reaction Steps

Using the procedure from Example 7A, 4-[(3-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-3-cyanopyridine (108 mg, 0.76 mmol), DIEA (0.2 ml, 1.14) and 1,4-dioxane (0.3 ml) to afford the title compound (91 mg), a yellow solid, in 62% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632838B2
Source datasetuspto-grants-2009_12
ORD IDord-08359d21d0f046faa58f4aae4ad9a46a
Source noteuspto-grants-2009_12