2,3-Dichloropyridine → 3-Chloro-2-{4-[(4-chlorophenyl)sulfonyl]piperidin-1-yl}pyridine

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Reaction Steps

Using the procedure from Example 7A, 4-[(4-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2,3-dichloropyridine (114 mg, 0.76 mmol), DIEA (0.27 ml, 1.52) and 1,4-dioxane (0.3 ml) at 190° C. to afford the title compound (56 mg), a white solid, in 40% yield.

Provenance & Evidence