HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3,5-Dichloro-4-{4-[(4-chlorophenyl)sulfonyl]piperidin-1-yl}pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[(4-Chlorophenyl)sulfonyl]piperidine | HCID 2761072 | — |
| Reactant | 3,4,5-Trichloropyridine | HCID 3786531 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,5-Dichloro-4-{4-[(4-chlorophenyl)sulfonyl]piperidin-1-yl}pyridine | HCID 68552367 | 33.1% |
Reaction Steps
Using the procedure from Example 7A, 4-[(4-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 3,4,5-trichloropyridine (141 mg, 0.76 mmol), DIEA (0.27 ml, 1.52) and 1,4-dioxane (0.3 ml) at 190° C. to afford the title compound (51 mg), a white solid, in 33% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-51b7aa4676c94d3082e21a061ba04021 |
| Source note | uspto-grants-2009_12 |