Diisopropylethylamine → 2-{4-[(4-Chlorophenyl)sulfonyl]piperidin-1-yl}-3-fluoropyridine

Participants

Reaction Steps

Using the procedure from Example 7A, 4-[(4-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-3-fluoropyridine (78 μl, 0.76 mmol), DIEA (0.27 ml, 1.52) and 1,4-dioxane (0.3 ml) at 190° C. to afford the title compound (18 mg), a white solid, in 13% yield.

Provenance & Evidence