HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2-{4-[(4-Chlorophenyl)sulfonyl]piperidin-1-yl}-4-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyridine | HCID 144958 | — |
| Reactant | 4-[(4-Chlorophenyl)sulfonyl]piperidine | HCID 2761072 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-{4-[(4-Chlorophenyl)sulfonyl]piperidin-1-yl}-4-(trifluoromethyl)pyridine | HCID 68551924 | 32% |
Reaction Steps
Using the procedure from Example 1A, 4-[(4-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-4-(trifluoromethyl)pyridine (99 μl, 0.76 mmol), DIEA (0.27 ml, 1.52) and 1,4-dioxane (0.3 ml) at 190° C. to afford the title compound (49 mg), an off-white solid, in 32% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-c4e3d4a8cf6549b39e6e23a9cb60445a |
| Source note | uspto-grants-2009_12 |