HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloropyridine → 2-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}-3-chloropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloropyridine | HCID 16988 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[(4-Tert-butylphenyl)sulfonyl]piperidine | HCID 18538636 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}-3-chloropyridine | HCID 68553137 | 28.3% |
Reaction Steps
Using the procedure from Example 7A, 4-[(4-tert-butylphenyl)sulfonyl]piperidine (100 mg, 0.36 mmol) was reacted with 2,3-dichloropyridine (108 mg, 0.72 mmol), DIEA (0.25 ml, 1.44) and 1,4-dioxane (0.3 ml) at 185° C. to afford the title compound (40 mg), a white solid, in 28% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-40e8653ea05345de921f79ed491addcc |
| Source note | uspto-grants-2009_12 |