HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Isoquinoline, 1-chloro- | HCID 140539 | — |
| Reactant | 4-[(4-Tert-butylphenyl)sulfonyl]piperidine | HCID 18538636 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}isoquinoline | HCID 68553637 | 18.5% |
Reaction Steps
Using the procedure from Example 7A, 4-[(4-tert-butylphenyl)sulfonyl]piperidine (150 mg, 0.53 mmol) was reacted with 1-chloroisoquinoline (183 mg, 1.06 mmol), DIEA (0.37 ml, 2.12) and 1,4-dioxane (0.2 ml) at 185° C. to afford the title compound (40 mg), a white solid, in 18% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-7ce0c7f6e8164cb2873fa335c36c3981 |
| Source note | uspto-grants-2009_12 |