2-Chloroquinoline → 2-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}quinoline

Participants

Reaction Steps

Using the procedure from Example 7A, 4-[(4-tert-butylphenyl)sulfonyl]piperidine (150 mg, 0.53 mmol) was reacted with 2-chloroquinoline (175 mg, 1.06 mmol), DIEA (0.37 ml, 2.12) and 1,4-dioxane (0.2 ml) at 185° C. to afford the title compound (39 mg), a white solid, in 18% yield.

Provenance & Evidence