2-Chlorobenzenesulfonyl chloride → HCID 68553066, compound

HRID 1868102Notes

Reaction equation

HRID 1868102 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[C:4]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26]>>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([NH:15][CH:12]1[CH2:13][CH2:14][N:9]([C:4]2[C:3]([C:2]([F:16])([F:1])[F:17])=[CH:8][CH:7]=[CH:6][N:5]=2)[CH2:10][CH2:11]1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 11413885HCID 11413885, compound

Product 1

HCID 68553066HCID 68553066, compoundYield 41.4%

Procedure

1-[3-(trifluoromethyl)pyridin-2-yl]piperidin-4-amine (100 mg, 0.42 mmol) was reacted with 2-chlorobenzenesulfonyl chloride (106 mg, 0.50 mmol) to afford the title compound (73 mg), a white solid, in 41% yield.

Sources & evidence

ORD record
ord-c4dc017ff7d646a09f962f37b558b62e
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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