3-Chlorobenzenesulphonyl chloride → HCID 68552941, compound

HRID 1868103Notes

Reaction equation

HRID 1868103 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[C:4]([N:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[Cl:18][C:19]1[CH:20]=[C:21]([S:25](Cl)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1>>[Cl:18][C:19]1[CH:20]=[C:21]([S:25]([NH:15][CH:12]2[CH2:13][CH2:14][N:9]([C:4]3[C:3]([C:2]([F:16])([F:1])[F:17])=[CH:8][CH:7]=[CH:6][N:5]=3)[CH2:10][CH2:11]2)(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 11413885HCID 11413885, compound

Product 1

HCID 68552941HCID 68552941, compoundYield 40.3%

Procedure

Using the procedure from Example 17A, Step 17C, 1-[3-(trifluoromethyl)pyridin-2-yl]piperidin-4-amine (100 mg, 0.42 mmol) was reacted with 3-chlorobenzenesulfonyl chloride (106 mg, 0.50 mmol) to afford the title compound (71 mg), a white solid, in 40% yield.

Sources & evidence

ORD record
ord-a84a19418a0943298007b441ea31d3ea
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…