HCID 68549405, compound → HCID 57418442, compound

Participants

Reaction Steps

Prepared according to the synthesis of Example 29EY in Step 4C from (R)-tert-butyl 4-(5-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)thiophen-2-yl)piperidine-1-carboxylate (150 mg, 0.253 mmol) in DCM (3 mL) and TFA (1 mL), purified by SiO2 column eluted with EtOAc/MeOH to give the titled compound as a white solid (75 mg, 60%). HRMS: calcd for C21H25F4N3O2S2+H+, 492.13970. found (ESI-FTMS, [M+H]1+), 492.14043.

Provenance & Evidence