HCID 68552252, compound → HCID 57418374, compound

Participants

Reaction Steps

A solution of 4-(4-Fluoro-2-trifluoromethyl-phenyl)-2-methyl-1-(3-nitro-benzenesulfonyl)-piperazine (330 mg, 0.8 mmol) and a catalytic amount of 10% Pd/C in EtOAc (25 mL) was stirred under H2 (1 atm) at ambient temperature for two hours, after which the reduction was judged complete by TLC. The H2 removed under vacuum, and the reaction mixture was filtered through celite, and rinsed with EtOAc (3×25 mL), and the filtrate was concentrated in vacuo, affording 180 mg of the desired sulfonamide in >95% purity (62% yield). HRMS: calcd for C18H19F4N3O2S+H+, 418.12068. found ([M+H]+), 418.12119.

Provenance & Evidence