HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-2-methoxythiophene → 4-Amino-2-(2-methoxy-thiophen-3-yl)-thieno[3,2-c]pyridine-7-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-2-methoxythiophene | HCID 10465187 | — |
| Reactant | 4-Amino-2-Bromothieno[3,2-C]pyridine-7-Carboxamide | HCID 58840713 | — |
| Product | 4-Amino-2-(2-methoxy-thiophen-3-yl)-thieno[3,2-c]pyridine-7-carboxylic acid amide | HCID 58840755 | — |
Reaction Steps
92 was prepared from 3-bromo-2-methoxythiophene 91 (Zhang, Y.; Hornfeldt, A.-B.; Gronowitz, S.; Stalhandske, C. Acta Chemica Scand. 1994, 48, 843-849) and 4-amino-2-bromo-thieno[3,2-c]pyridine-7-carboxylic acid amide in a similar manner to that described for Example 14. 1H NMR (400 MHz, d6-DMSO) δ: 4.10 (s, 3H), 7.13 (d, J6.0 Hz, 1H), 7.28 (d, J6.0 Hz, 1H), 7.69-7.78 (br s, 1H), 8.19 (s, 1H), 8.20-8.30 (br s, 1H), 8.40 (s, 1H), 8.60-8.80 (br s, 2H). MS (EI) m/z (M+H+) 306, (2M+H+) 611.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07635695B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-4430dbad507b400aa9a0dda59af66235 |
| Source note | uspto-grants-2009_12 |