反应详情

To a solution of benzyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate (0.50 g, ex Maybridge) in 1,4-dioxan (5 ml) was added 3-chloroaniline (0.85 ml) and the solution stirred at room temperature for 15 h. 1,4-Dioxan was removed under reduced pressure and ethyl acetate (15 ml) added. The solution was washed sequentially with 2N hydrochloric acid (10 ml) and water (3×10 ml), dried (MgSO4), evaporated and triturated with hexane to afford benzyl 2-(3-chlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylate (524 mg).

1. custom1,4-Dioxan was removed under reduced pressure and ethyl acetate (15 ml)
2. additionadded
3. washThe solution was washed sequentially with 2N hydrochloric acid (10 ml) and water (3×10 ml)
4. dry with materialdried (MgSO4)
5. customevaporated
6. customtriturated with hexane